�Just beforehand of the expected release of clinical practice guidelines on Familial Hypercholesterolaemia (FH) by the influential National Institute for Clinical Excellence (NICE), Tepnel Life Sciences PLC (AIM: TED) today announced the launch of a DNA test for the early detection of FH, a genetic condition that predisposes individuals to high blood cholesterol levels and increased risk of cardiovascular disease. The CE marked Elucigene FH20 outfit, validated for in vitro diagnostic use, can rapidly determine the 20 genetic mutations most commonly found in a UK based population, that are responsible for the disease.
FH is a public health problem end-to-end the world with an estimated 10 million multitude affected, the majority of who testament suffer an adverse coronary thrombosis event before they ar 65 years old. A common genetic disorder, the potentially lethal condition occurs in 1 of 500 people in Europe and North America. In the United Kingdom it is estimated that up to 110,000 people ar affected with FH and 75% of these cases are undiagnosed.
The NICE consultation on a drawing of guidelines for employment by the National Health Service (NHS) in England and Wales is nowadays being finalized with anticipated publication for August, 2008. NICE is expected to recommend that all FH patients are offered a DNA test with subsequent cascade cover to be performed where the mutation is identified in a patient.
In a recent UK fender study the test identified a 52% mutation detection rate in a sample of 110 FH heterozygous patients. "The study findings validate Elucigene FH20 as a worthful component for future FH screening programs in the United Kingdom, providing a cost-efficient and simple method for confirmatory a person has hereditary this mortal condition," aforementioned Ben Matzilevich, Tepnel's Chief Executive Officer. "For effective treatment, early identification of persons with FH is essential and FH20 offers the NHS the right tool at the right time to implement the new clinical practice guidelines."
Currently late-stage clinical indications that propose a patient is affected with FH are increased serum cholesterin concentration, tendon xanthomas and premature coronary thrombosis heart disease. Treatment with statins to lower cholesterol levels is effective, just preventative treatment requires early diagnosis. Pre-symptomatic identification of FH individuals can insure the health risks of high cholesterin are minimized through seize modifications to diet and lifestyle.
Early detection requires identification of genetic mutations of the low-density lipoprotein receptor (LDLR) gene, the apoloiprotein B-100 (Apo B) gene or the proprotein converatse subtilisin/kexin type 9 (PCSK9) gene which are the suit of FH. Unlike other genetic diseases such as cystic fibrosis, where an affected affected role must inherit two copies of the mutated factor, FH has an autosomal dominant traffic pattern of inheritance and requires the affected patient to carry solely one copy of the mutated cistron.
While such DNA analysis and chromosomal mutation detection is crucial for the definitive diagnosis of FH, the testing can be irksome and expensive due to the exceedingly heterogeneous nature of the LDLR factor.
Following the confirmation of mutation status of an FH patient using the rapid and cost-effective Elucigene FH20 check, the new Tepnel test can be used to detect early previously undiagnosed family members with FH through shower screening programs.
The Elucigene FH20 examine is developed and manufactured within quality systems commissioned to ISO9001 and ISO13485 and complies with the European Community Directive 98/79/EC. The test is non for use in diagnostic procedures in the USA.
About Tepnel Life Sciences PLC
Tepnel Life Sciences (AIM:TED) is a UK-based international life sciences products and services Group with iI divisions, Molecular Diagnostics and Research Products & Services. The Company has laboratories, manufacturing and operations in the USA, UK and France with over cc employees. Tepnel provides test kits, reagents and services to deuce highly synergistic markets, these being Molecular Diagnostics and Biomedical Research. The Company's strategy has been to identify high growth niche opportunities inside these multi-billion pound markets. Tepnel focuses on these niche operations with internally developed products, patents, expertise and know-how as well as strategic acquisitions, to develop a leadership position within these defined market segments.
Tepnel Life Sciences PLC
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Wednesday, 3 September 2008
Thursday, 14 August 2008
Jenny Lindfors, When The Night Time Comes
Irish creative person Jenny Lindfors is the latest hopeful debutant to join the large and growing concourse of slightly retro, more often than not acoustic isaac M. Singer songwriters clamoring for your attention. The competition is tough out there. When The Night Time Comes could be described as a romanticistic song cycle � whether it's all about one relationship or several � beginning and ending as it does with songs themed about desire and lust, and getting dark and emotionally messy in the middle. Hardly a fresh topic, but the tale is in the telling, so is she up to it?
She's sure blessed with a smashing, bluesy vocalisation and knows how to use it, coming across a bit like Bonnie Raitt or Susan Tedeschi on the confident opener Night Time, which, wish several other tracks has an ever-so-slightly 'ethnic' vibration courtesy of James Guilmartin's djembe drum. There's a distinctly CSNY flavour to the vocal harmonies on Voodoo, and definite dark glasses of Joni Mitchell on the ballads I Don't Really Want You Here and By The Wayside, while Sheryl Crow may have been the role model on the more upbeat Time Warp and Play It Away.
Lindfors plays guitar, banjo, ukulele and percussion and even does her own backing vocals at times as well as producing and penning all the material. Whether that was down to the constraints of the budget or an outsized ego, there's a little too much of Jenny and non enough of other masses on this overly autobiographical effort. It sags a third of the direction in with the schmaltzy cello and awkward lyrics of Lovestage, and things get worse with Looming, which suffers similar problems.
Lindfors is at her best on the more rocking tracks when the focus is more on her voice than what she's saying. By the time her 40 minutes ar up, you may be wishing she'd either branch out her issue matter or try singing someone else's songs � the corporeal isn't impregnable enough to engage end-to-end � and perhaps bring forth someone else in to produce.
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Wednesday, 6 August 2008
'Garfield Minus Garfield' equals book deal
Quick math: What do you contract when you remove the title fictitious character from a legendary comic strip and post the eerily entertaining results online?
A book deal.
In October, Ballantine Books will publish �Garfield Minus Garfield,� a version of the fat-cat comic strip that removes all characters leave out for Jon Arbuckle. The results, posted daily at the wildly popular garfieldminusgarfield.net, is a pleasurably creepy look into the lonely life of a young, schizophrenic bachelor.
The full-color book release coincides with the 30th anniversary of �Garfield� and will hit shelves simultaneously with a new anthology, �Thirty Years of Laughs and Lasagna: The Life and Times of a Fat, Furry Legend.�
The coupling of the Web comic and original strip was made possible by an endorsement from �Garfield� creator Jim Davis, who became a fan of �Garfield Minus Garfield� creator Dan Walsh and granted permission to race his original work aboard the Web comics in the forthcoming book.
�I consider it�s an inspired thing to do,� Davis said in a press release. �I want to thank Dan for enabling me to see another side of �Garfield.� Some strips he chose were slappers: �Oh, I could have left that out, it would have been funnier.� �
Naturally, Walsh is prestigious by the praise - and plausibly relieved a lawsuit didn�t drop on his doorstep. It�s not often an artist endorses something that completely alters what originally made him or her famous.
�Thanks to the awful generosity and humor of Jim Davis, �Garfield Minus Garfield� is about to become a book, and I�m absolutely honored to be a part of it,� said the Dublin, Ireland-based Walsh.
�Rock of Love 3� casting calls
As anyone wHO watched VH1�s �Rock of Love 2 with Bret Michaels� could have predicted, the leathery Poison frontman did non find true love with the show�s winner, Ambre Lake.
So fix ready for the third base season of �Rock of Love,� which is property open casting calls this weekend in New York.
Interested ladies of varying rupture sizes should start film editing up their favorite Ed Hardy tank-top and hop on the Fung Wah for open cast on Friday at Porky�s NYC (55 West twenty-first St.) and Sunday at Porky�s Hampton Bays (80 East Montauk Highway). Both casting calls start at 9 p.m.
If traveling to the Dirty Apple and Strong Island isn�t plausible, ladies can e-mail NYRock@realtalentcasting.com. Be sure to include your name, age, placement, contact info, bio, a few pics and most recent STD test results. (OK, we�re kidding nigh that last one. We think.)
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Friday, 27 June 2008
Madonna tickets selling fast: Live Nation
NEW YORK (Reuters) - Madonna fans have turned out in record numbers for her world tour, concert promoter Live Nation Inc said on Thursday, seeking to knock down reports the Material Girl is losing her appeal.
The Los Angeles company said Madonna had sold more than one million tickets -- over 90 percent of those available -- for Madonna's 42-date global "Sticky & Sweet" tour, which kicks off in Cardiff, Wales on August 23.
Live Nation is trying to transform itself into a comprehensive music company, offering artists recording contracts and merchandising deals, as well as touring and access to its live venues. Madonna was one of the biggest names the company has signed for a reported $120 million contract.
The New York Post reported on Tuesday that Madonna was failing to sell out certain venues, including a November date at the Dodger Stadium in Los Angeles that sold just 27,000 of 43,000 seats.
Live Nation spokesman John Vlautin confirmed the Los Angeles numbers, but said the global tour's ticket sales are on target to gross more than $250 million, which would shatter Madonna's own previous record for a female artist of $195 million from "Confessions On A Dancefloor" tour two years ago.
It has been a difficult month for Live Nation, with speculation mounting on whether the company overpaid to sign artists such as Madonna and rapper Jay-Z to be part of its new '360-degree' business model.
Live Nation lost its chairman, Michael Cohl, last week after a fallout with Chief Executive Michael Rapino over this strategy. Cohl, who was head of Live Nation's artists division, had wanted to sign artists at a quicker pace, but Rapino wanted to sign around four to six marquee names a year. Cohl is now a consultant to the company.
There has also been concern the slowing U.S. economy would hurt nonessential items such as rock concert tickets, which can cost up to $200 each for major artists -- the larger share of Live Nation's revenue streams.
Live Nation's management has said it is has seen no impact from the slowing economy, Vlautin said.
(Reporting by Yinka Adegoke; Editing by Andre Grenon)
The Los Angeles company said Madonna had sold more than one million tickets -- over 90 percent of those available -- for Madonna's 42-date global "Sticky & Sweet" tour, which kicks off in Cardiff, Wales on August 23.
Live Nation is trying to transform itself into a comprehensive music company, offering artists recording contracts and merchandising deals, as well as touring and access to its live venues. Madonna was one of the biggest names the company has signed for a reported $120 million contract.
The New York Post reported on Tuesday that Madonna was failing to sell out certain venues, including a November date at the Dodger Stadium in Los Angeles that sold just 27,000 of 43,000 seats.
Live Nation spokesman John Vlautin confirmed the Los Angeles numbers, but said the global tour's ticket sales are on target to gross more than $250 million, which would shatter Madonna's own previous record for a female artist of $195 million from "Confessions On A Dancefloor" tour two years ago.
It has been a difficult month for Live Nation, with speculation mounting on whether the company overpaid to sign artists such as Madonna and rapper Jay-Z to be part of its new '360-degree' business model.
Live Nation lost its chairman, Michael Cohl, last week after a fallout with Chief Executive Michael Rapino over this strategy. Cohl, who was head of Live Nation's artists division, had wanted to sign artists at a quicker pace, but Rapino wanted to sign around four to six marquee names a year. Cohl is now a consultant to the company.
There has also been concern the slowing U.S. economy would hurt nonessential items such as rock concert tickets, which can cost up to $200 each for major artists -- the larger share of Live Nation's revenue streams.
Live Nation's management has said it is has seen no impact from the slowing economy, Vlautin said.
(Reporting by Yinka Adegoke; Editing by Andre Grenon)
Thursday, 19 June 2008
Sucker Djs feat. Tiger Lily
Artist: Sucker Djs feat. Tiger Lily
Genre(s):
Trance
Discography:
Firework
Year: 2006
Tracks: 3
Jennifer Aniston Joins John Mayer Backstage At His Concert
Saturday, 7 June 2008
Pitt and Jolie to marry this summer?
Brad Pitt and Angelina Jolie are to marry on a yacht this summer, according to reports.
The Hollywood couple will reportedly wed in an intimate ceremony after Jolie, who is rumoured to be expecting twins, gives birth in France.
A source told Grazia magazine: "Brad has been talking about getting married for ages. He is totally devoted to her and their children. It is the right time for them to do this.
"It will be a strictly private affair. Brad did the big celebrity-packed wedding when he married Jennifer Aniston. This time it will be an intimate family gathering.
"Angelina has said there will be no big white dress or lots of flowers. At the moment they are looking at hosting a ceremony this summer on a yacht out in the ocean, miles from land, with just their children, Brad's close family and Angelina's brother."
According to the source, Jolie is also considering inviting her estranged father Jon Voight, however she wants brother James Haven to give her away.
The Hollywood couple will reportedly wed in an intimate ceremony after Jolie, who is rumoured to be expecting twins, gives birth in France.
A source told Grazia magazine: "Brad has been talking about getting married for ages. He is totally devoted to her and their children. It is the right time for them to do this.
"It will be a strictly private affair. Brad did the big celebrity-packed wedding when he married Jennifer Aniston. This time it will be an intimate family gathering.
"Angelina has said there will be no big white dress or lots of flowers. At the moment they are looking at hosting a ceremony this summer on a yacht out in the ocean, miles from land, with just their children, Brad's close family and Angelina's brother."
According to the source, Jolie is also considering inviting her estranged father Jon Voight, however she wants brother James Haven to give her away.
Monday, 26 May 2008
Ashlee Simpson IS pregnant, plans to marry in May
Ashlee Simpson IS pregnant and is planning to wed her fiance Pete Wentz next month, it has been claimed.
Citing a source close to the Simpson family, People magazine claims the pair — who announced their engagement last week — are planning to get married at a private residence in Southern California.
Wentz, 28, initially blasted the pregnancy rumors, calling them a “witch hunt.”
Citing a source close to the Simpson family, People magazine claims the pair — who announced their engagement last week — are planning to get married at a private residence in Southern California.
Wentz, 28, initially blasted the pregnancy rumors, calling them a “witch hunt.”
Friday, 23 May 2008
Amy Winehouse chops off her beehive
Amy Winehouse chops off her beehive
Troubled principal Amy Winehouse has shocked fans by chopping away her trademark hive coif.
The 'Back To Black' singer has had her fuzz cut into a short crop, and has swapped her once dark locks for a peroxide blond coif.
The newly dash is reported to have been the shape of her hairstylist Alex Foden, world Health Organization lives in the sami east British capital flat kibosh as Winehouse.
A source tells Brits newspaper The Sun, "She just said she felt like it. She'd view around having a blond beehive but decided on the shorter look."
A interpreter for the star adds, "She wanted a newly search for the Newly Twelvemonth."
Muse rock the Royal Albert Hall
Extras wins at Golden Globes
Extras wins at Golden Globes
The Ricky Gervais-starring comedy 'Extras' was named Best Comedy Series in the TV categories at the Golden Globe Awards press conference in Los Angeles shoemaker's last night.
The award for Best TV Play went to 'Mad Men', with its ace, John the Divine Hamm, named C. H. Best Doer in a TV Drama Series.
John Herschel Glenn Jr. Close won the Best Actress in a TV Dramatic event Series award for her execution in 'Damages'.
The award for Topper Actor in a TV Comedy Series went to David Duchovny for 'Californication', with Tina Fey winning the Topper Actress in a TV Comedy Series prize for '30 Rock'.
On that point were trine awards for the Channel 4-screened TV celluloid 'Longford': it won the Best Mini-Series or Motion Video Made for Television award, with its stars, Jim Broadbent and Samantha Jelly Roll Morton, winning the Topper Worker and Best Support Actress awards.
Queen Latifah north Korean won the C. H. Best Performance by an Actress in a Mini-Series or TV Motion-picture show for 'Life Support' and Jeremy Piven south Korean won the Best Supporting TV Actor honor for 'Entourage'.
Read about the winners in the Golden Globes Cinema categories here.
Irish stars honoured at British Film Awards
Irish stars honoured at British Film Awards
Privy Carney, the writer/ director behind 'Once', and 'Atonement' camera operator Seamus McGarvey were amongst the winners at the British people Film Awards.
Carney took the dirty money for Most Promising Newcomer in the awards designed to honor the Brits moving-picture show industry, despite the fact that he is Irish people.
Armagh's Seamus McGarvey was one of trey winners for 'Atonement', which also took prizes for costume design and production.
In the other categories Helena Bonham-Carter was named c. H. Best actress for two performances - in 'Sweeney Sweeney Todd: The Monster Barber Of Fleet Street' and low-key drama 'Conversations With Other Women'.
Irish citizen Daniel Day-Lewis won topper doer for his theatrical role as a Texan oil prospector in 'There Will Be Blood'. The performance has already earned him a Golden Ball and he is heatedly tipped for Bafta and Oscar resplendency afterwards this month.
Julie Dame Agatha Mary Clarissa Christie, likewise a front-runner for Oscar success with 'Away From Her', received the Alexander Walker Special Award for outstanding contribution to celluloid.
Pleasure Division biopic 'Control' was the surprisal victor of the best cinema award, beating 'Atonement' and 'There Will Be Blood'. It likewise south Korean won best screenplay.
Radiohead guitar player Jonny Greenwood received the best plastic film score award for 'There Will Be Blood'.
Miley Cyrus To Team Up With John Travolta?
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